Adapting fasting plasma glucose threshold for GDM diagnosis according to the population distribution – An approach to the Danish paradox

Aims To examine third trimester fasting venous plasma glucose (FVPG) according to the distribution of a Danish population pregnant women and identify potential local FVPG thresholds for GDM diagnosis related risks adverse pregnancy outcomes. Methods In observational Odense Child Cohort (OCC) study, 1516 had measured at 27–28 weeks’ gestation were considered normal by criteria remained untreated. Maternal from OCC standardized mean standard deviation calibrated data Hyperglycemia Adverse Pregnancy Outcome (HAPO) study. Associations between maternal clinical anthropometric outcomes analysed. Potential cut points identified. Results Unadjusted areas under ROC curve discriminate large gestational age (LGA) hypertensive disorders 0.61 (95% CI 0.56, 0.67) 0.57 0.52, 0.63), respectively. The Youden point LGA was 5.5 mmol/L 5.0 pregnancy. Conclusions This study identified locally appropriate 5.7 based on risk in should be validated prospectively other cohorts.